Ectopic Expression of an Activated RAC inArabidopsisDisrupts Membrane Cycling
نویسندگان
چکیده
منابع مشابه
Ectopic expression of an activated RAC in Arabidopsis disrupts membrane cycling.
Rho GTPases regulate the actin cytoskeleton, exocytosis, endocytosis, and other signaling cascades. Rhos are subdivided into four subfamilies designated Rho, Racs, Cdc42, and a plant-specific group designated RACs/Rops. This research demonstrates that ectopic expression of a constitutive active Arabidopsis RAC, AtRAC10, disrupts actin cytoskeleton organization and membrane cycling. We created t...
متن کاملCell cycling with Rac
hen endothelial cells adhere to the extracellular matrix protein fibronectin, they can proliferate in response to growth factors. Adhesion to laminin, however, brings their cell cycles to a dead stop. Why? Given that the response depends on the composition of the extracellular matrix, Filippo Giancotti and his colleagues at the Memorial Sloan-Kettering Cancer Center (New York, NY) proposed in 1...
متن کاملMembrane traffic: Cycling lipids
One of the more fascinating problems in biology is to understand the nerve signalling that enables us to think and feel. The transmission of nerve impulses across synapses is accomplished by the release of signalling molecules, known as neurotransmitters, at nerve terminals. Neurotransmitters are stored in synaptic vesicles and, after the nerve has received the appropriate stimulus, they are re...
متن کاملRac-ing to the plasma membrane
The functional cycle of the Rac1 GTPase involves a large number of steps, including post-translational processing, cytosolic sequestration by RhoGDIs, translocation to specific subcellular localizations, activation by GDP/GTP exchange, inactivation by GTP hydrolysis, and re-formation of cytosolic Rac1/RhoGDI inhibitory complexes. Here, we summarize the current knowledge about the regulation of ...
متن کاملPlant Rac-like GTPases are activated by auxin and mediate auxin-responsive gene expression.
The auxin indole-3-acetic acid is a key plant hormone essential for a broad range of growth and developmental processes. Here, we show that auxin activates Rac-like GTPases (referred to as Rac/Rop GTPases), and they in turn stimulate auxin-responsive gene expression. In particular, we show that overexpressing a wild-type tobacco Rac/Rop GTPase, NtRac1, and its constitutively active mutant form ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2005
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e04-07-0562